Dean, School of PharmacyLawrence, Kansas 66045
Phone: (785) 864-3591
Fax: (785) 864-5265
Email: audus@ku.edu
Ph.D., University of Kansas School of Medicine, 1984; Postdoctoral, University of Kansas
The Audus laboratory pursues research on the application of endothelial and epithelial cell and tissue culture systems to study mechanisms of drug transport, metabolism, and tissue permeability regulation. His research has included establishment of tissue culture systems comprised of brain microvessel endothelium (i.e., the blood-brain barrier), alveolar epithelium (i.e., the respiratory epithelial barrier), and trophoblasts (i.e., the placental barrier).
In general, Dr. Audus' research group conducts investigations that are directed at developing a basic understanding of drug, tissue, disease, and environmental factors and mechanisms that regulate the distribution of drugs across epithelial and endothelial tissue interfaces into either the systemic circulation or specific tissue compartments from the vasculature. Specific examples of recent and ongoing research projects in Dr. Audus' group have included characterization of nutrient and peptide carriers, catecholamine and peptide regulation of permeability of the blood-brain barrier; macromolecule transfer mechanisms in alveolar epithelium; multidrug resistance and enzyme expression and induction in trophoblasts; and the transport and metabolism of drugs of abuse at the human placental barrier.
Avery, M.L., Meek, C.E., and Audus, K.L. (2003) The presence of inducible cytochrome P450 types 1A1 and 1A2 in the BeWo cell line. Placenta 24, 45-52.
Young, A.M., Allen, C.E., and Audus, K.L. (2003) Efflux transporters of the placenta. Adv. Drug Del. Rev. 55, 125-132.
Wimalasena, R., Audus, K.L., and Stobaugh, J.F. (2003) Rapid optimization of the post-column flurogenic ninhydrin reaction for the HPLC-based derivatization of bradykinin and related fragments. Biomed. Chromatography 17, 165-171.
Rice, A., Silverstein, P., and Audus, K.L. (2003) Brain microvessel endothelial cell cultures as in vitro models to study the blood-brain barrier, in Blood-Spinal and Brain Barriers in Health and Disease (Sharma, H.S., Ed.), pp 47-56, Academic Press, Inc., New York.
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The University of Kansas Medical Center