Sosland Family Professor of Pediatrics2401 Gillham Road
Kansas City, Missouri 64108
Phone: (816) 234-3592
Fax: (816) 234-3590
Email: wtruog@cmh.edu
MD, University of Chicago Pritzker School of Medicine, 1973
The long term goal of Dr. Truog and other investigators in the Pulmonary Developmental Biology Research Laboratories of Children’s Mercy Hospitals and Clinics at the University of Missouri - Kansas City School of Medicine is to improve understanding of how the lungs of newborn infants are injured, and to investigate new therapies for pulmonary disorders. One specific goal of the laboratory is to assess both beneficial and toxic effects of the potent therapeutic agent, inhaled nitric oxide, both at the bedside and in the laboratory. Our group has focused on studying potential toxicity of combined exposure to oxygen and to nitric oxide in neonatal piglets. We seek to learn about alterations in structural elements of the lung, as well as altered molecular expression and protein production of growth factors in the lung. Our parallel studies in humans have examined the impact of profoundly preterm delivery and its consequences. We have studied pulmonary microvascular development, assessing quantitatively by light and electron microscopy the state of the pulmonary microvasculature following exposure to oxygen and assisted ventilation.
Other studies undertaken in our laboratory include assessment, both in humans and in animals, of lipid and peptide mediators of pulmonary vascular reactivity and the effects of various pulmonary disorders on the metabolism of these vasoactive substances in the developing lung. Investigations in our laboratory also include the assessment of different patterns of lung inflation as provided by assisted breathing devices and their relative contributions to lung injury in immature lungs.
Participation in the Institute of Maternal-Fetal Biology at the University of Kansas School of Medicine will enhance our own research activities, encouraging sharing of our work with the complementary work of many other investigators interested in basic and translational aspects of developmental biology.
Ekekezie, I.I., Thibeault, D.W., Garola, R.E., and Truog, W.E. (2001) Monocyte chemoattractant protein-1 and its receptor CCR-2 in piglet lungs exposed to inhaled nitric oxide and hyperoxia. Pediatr. Res. 50, 633-640.
Olsen, S.L., Thibeault, D.W., Mabry, S.M., Norberg, M., and Truog, W.E. (2002) Platelet endothelial cell adhesion molecule-1 and capillary loading in premature infants with and without chronic lung disease. Pediatr. Pulmonol. 33, 255-262.
Ekekezie, I.I., Thibeault, D.W., and Truog, W.E. (2003) Endostatin and vascular endothelial cell growth factor (VEGF) in piglet lungs; effect of inhaled nitric oxide and hyperoxia, Pediatr Res. 53, 440-446.
Thibeault, D.W., Mabry, S.M., Ekekezie, I.I., Zhang, X., and Truog, W.E. (2003) Collagen scaffolding during development and its deformation with chronic lung disease. Pediatrics 111, 766-776.
Kaftan, H.A., Clark, P.L., Norberg, M., Garg, U., Thibeault, DW.,and Truog, W.E. (2003) Endogenous production of nitric oxide in endotoxemic piglets. Biol. Neonate 83, 42-48.
Truog, W.E., Castor, C.A., and Sheffield, M.J. (2003) Neonatal nitric oxide use: predictors of response and financial implications. J Perinatol 23, 128-132.
Truog, W.E. (2003) Genomic and complex neonatal disorders: maybe we’re getting somewhere. J. Perinatol. 23, 91-93.
Ballard, P.L., Merrill, J.D., Godinez, R.I., Godinez, M.H., Truog, W.E., and Ballard, R.A. (2003) Surfactant protein profile of pulmonary surfactant in premature infants. Am. J. Respir. Crit. Care Med. 168, 1123-1128.
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The University of Kansas Medical Center